Robust nitric oxide-releasing polymers and articles and methods of making and uses thereof
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorSean Hopkins
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Abstract
Described herein are nitric oxide releasing materials, methods of making nitric oxide releasing materials, and devices including nitric oxide releasing materials. The nitric oxide releasing material includes a polymer matrix having a plurality of polysiloxanes and nitric oxide-donating crosslinking moieties that covalently crosslink the polysiloxanes. Blood clotting or adhesion of a biomaterial to a surface, as well as biofilm formation can be prevented using the methods and materials described.
Claims26
A nitric oxide releasing material comprising a polymer matrix, wherein the polymer matrix comprises
- a plurality of polysiloxanes covalently crosslinked with a plurality of nitric oxide-donating crosslinking moieties;
- wherein the nitric oxide-donating crosslinking moieties are present in an amount from about 0.1 micromoles to about 0.801 micromoles per milligram of the polymer matrix;
- wherein each of the nitric oxide-donating crosslinking moieties comprise a S-nitroso-N-acetyl-penicillamine group covalently attached thereto;
- and
- wherein the plurality of polysiloxanes have a kinematic viscosity of about 2,550 cSt to about 3,570 cSt prior to crosslinked in the polymer matrix.
A nitric oxide-releasing material produced the method comprising:
- crosslinking a plurality of polysiloxanes with a plurality of amine-functionalized crosslinking moieties to produce a crosslinked polymer matrix;
- covalently attaching a thiolactone to an amine in the amine-functionalized crosslinking moieties to produce a thiol-functionalized crosslinked polymer matrix;
- and
- nitrosating the thiol in the thiol-functionalized crosslinked polymer matrix in the presence of an organic acid to produce the nitric oxide-releasing material comprising nitric oxide-donating crosslinking moieties,
- wherein the nitric oxide-donating crosslinking moieties are present in an amount from about 0.1 micromoles to about 0.801 micromoles per milligram of the polymer matrix;
- wherein each of the nitric oxide-donating crosslinking moieties comprise a S-nitroso-N-acetyl-penicillamine group covalently attached thereto;
- and
- wherein the plurality of polysiloxanes have a kinematic viscosity of about 2,550 cSt to about 3,570 cSt prior to crosslinked in the polymer matrix.
A method for making a nitric oxide-releasing material the method comprising:
- crosslinking a plurality of polysiloxanes with a plurality of amine-functionalized crosslinking moieties to produce a crosslinked polymer matrix;
- covalently attaching a thiolactone to an amine in the amine-functionalized crosslinking moieties to produce a thiol-functionalized crosslinked polymer matrix;
- and
- nitrosating the thiol in the thiol-functionalized crosslinked polymer matrix in the presence of an organic acid to produce the nitric oxide-releasing material comprising nitric oxide-donating crosslinking moieties,
- wherein the nitric oxide-donating crosslinking moieties are present in an amount from about 0.1 micromoles to about 0.801 micromoles per milligram of the polymer matrix;
- wherein each of the nitric oxide-donating crosslinking moieties comprise a S-nitroso-N-acetyl-penicillamine group covalently attached thereto;
- and
- wherein the plurality of polysiloxanes have a kinematic viscosity of about 2,550 cSt to about 3,570 cSt prior to crosslinked in the polymer matrix.
Dependencies are inferred from the claim text.