Kit comprising adhesive hydrogel and impregnating fluid
AssigneesEmpa EidgenöSsische MaterialprüFungs- Und Forschungsanstalt, ETH Zurich
InventorsAlexandre Anthis, Inge Herrmann, Tino Matter
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Abstract
A kit of parts including two components, the first component being a patch including a non-degradable synthetic hydrogel and the second component being an impregnating fluid, which, upon in-situ polymerisation, anchors the patch on a tissue. The patch may include additional layers including sensing components or therapeutic components. In addition, the use of the kit of parts and the use of an impregnating fluid in surgery, in particular as suture or staple supports, e.g. suture or staple supports in the abdominal region such as intestinal anastomosis sites, or for sealing of artificial stoma.
Claims15
A kit of parts ready to use in a surgical method comprising a first part and a second part, wherein
- the first part is a shaped article in the form of a patch for application on a sutured site, a stapled site or a stoma site of a subject in need thereof, the patch comprising a hydrogel support layer, optionally a backing layer, and optionally functional components selected from sensing components, and therapeutic components, and
- the second part is an impregnating fluid for application on a sutured site, a stapled site or a stoma site of a subject in need thereof, and on the patch, wherein the impregnating fluid comprises a pharmaceutically acceptable liquid, curable monomers, optionally curing initiators, and optionally additives;
- wherein the curable monomers present in the impregnating fluid are in an uncured, monomeric state when the impregnating fluid is not applied on the patch, and
- wherein
- the hydrogel support layer comprises a non-degradable, synthetic hydrogel;
- and
- the optional backing layer comprises a non-adhesive polymer;
- and
- the liquid is selected from water and/or glycerol;
- and
- the optional curing initiator is adapted for curing the curable monomers;
- and
- the patch and the impregnating fluid are each separately packed for transport and/or sale and prior to the use in a surgical method;
- and
- the patch is impregnated with the fluid shortly before application on a tissue, such that curing of the monomers that are present in the impregnating fluid is initiated after application of the patch.
An impregnating fluid for use in a surgical method for adhering a patch to a sutured site, a stapled site or a stoma site of a subject in need thereof, wherein
- the impregnating fluid comprises a pharmaceutically acceptable liquid selected from water and/or glycerol;
- and curable monomers;
- the curable monomers present in the impregnating fluid are in an uncured, monomeric state when the impregnating fluid is not applied on the patch;
- and
- the patch comprises a hydrogel support layer comprising a non-degradable, synthetic hydrogel.
Dependencies are inferred from the claim text.