Radiopharmaceutical compositions for actinium in targeted radionuclide therapy
AssigneeCurium US LLC
InventorsJarno Jalomäki, Salla Seppänen, Riku Parviainen
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Abstract
The present disclosure provides a high-energy, low toxicity radiopharmaceutical composition comprising actinium that performs as an anti-tumor agent for targeted radionuclide therapy and has improved shelf-life stability. Specifically, the radiopharmaceutical composition may include 225Ac-PSMA I&T, sodium ascorbate, and optionally hydrochloric acid. The radiopharmaceutical composition may be suitable for administration to a patient in need thereof, such as for the purpose of treating prostate cancer.
Claims24
A method comprising:
- administering a radiopharmaceutical composition to a patient in need thereof, wherein the composition comprises:
- 225Ac-PSMA I&T in an amount that provides a radioactivity concentration of 250 kBq/mL to 1100 kBq/mL;
- and
- sodium ascorbate in an amount of 0.1 mg/mL to 100 mg/mL;
- wherein the composition has a radiochemical purity of 90% to 100% when administered;
- and
- wherein the composition has a radiochemical purity of ≥90% at least 72 hours from production when stored at about 5° C. to about 40° C.
A method comprising:
- administering a radiopharmaceutical composition to a patient in need thereof, wherein the composition comprises 225Ac-PSMA I&T in an amount that provides a radioactivity concentration of 250 kBq/mL to 1100 kBq/mL,
- wherein the composition has a radiochemical purity of 95% to 100% when administered, and
- wherein the composition has a radiochemical purity of ≥95% at least 72 hours from production when stored at about 5° C. to about 40° C.
A method of administering a radiopharmaceutical composition, the method comprising injecting the composition into a patient in need thereof, the composition comprising 225Ac-PSMA I&T and sodium ascorbate in a solution having a pH of 5.5 to 7.5, wherein the solution has a radiochemical purity of more than 90% when administered.
Dependencies are inferred from the claim text.