Cobalt-doped iron oxide nanoparticles and methods for making and using
AssigneesOregon State University, Oregon Health & Science University
InventorsOlena Taratula, Oleh Taratula, Ananiya A. Demessie, Ov Slayden, Youngrong Park
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Abstract
Disclosed herein are embodiments of a nanoparticle suitable for use in providing hyperthermia treatment. The nanoparticle may be a cobalt-doped iron oxide nanoparticle. Also disclosed are compositions comprising the nanoparticle. The composition may further comprise a polymer and/or a targeting moiety. Further disclosed and methods for making the nanoparticle and the composition, and embodiments of a method for using the nanoparticle or a composition thereof. The nanoparticle may be useful for treating cancer, and/or endometriosis.
Claims20
A composition comprising:
- a polymer;
- and
- a non-spherical nanoparticle comprising from greater than zero to 5 atom % cobalt, from 18 atom % to 60 atom % iron, and from greater than 35 atom % to 82 atom % oxygen, in amounts relative to each other, such that the total amount of cobalt, iron and oxygen is 100 atom %;
- wherein the nanoparticle has a specific absorption rate of from 2,500 W g−1 to 20,000 W g−1.
A non-spherical nanoparticle comprising from 1 atom % to 5 atom % cobalt, from 18 atom % to 45 atom % iron, and from 35 atom % to 80 atom % oxygen, such that a total amount of cobalt, iron and oxygen in the nanoparticle is 100%, the nanoparticle having a size of from 4 nm to less than 50 nm, a specific absorption rate of from 2,500 W g−1 to 20,000 W g−1, and no observable crystalline defects under high resolution TEM.
A method, comprising:
- forming a solution or suspension comprising a first organic solvent and a non-spherical nanoparticle having a specific absorption rate of from 2,500 W g−1 to 20,000 W g−1, the non-spherical nanoparticle comprising from greater than zero to 5 atom % cobalt, from 18 atom % to 60 atom % iron, and from greater than 35 atom % to 82 atom % oxygen, in amounts relative to each other, such that the total amount of cobalt, iron and oxygen is 100 atom %;
- forming a mixture comprising the solution or suspension and a polymer in a second organic solvent;
- and
- isolating a composition comprising the non-spherical nanoparticle and the polymer.
Dependencies are inferred from the claim text.