Compositions for targeting muscle cells and uses thereof
AssigneesCavalry Biosciences, Inc., University of Florida Research Foundation, Inc.
InventorsNathaniel Eames David, Robert N. O'Brien, Timothy R. Stowe, Patrick B. Ventura, James W. West, Elisabeth Barton
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Abstract
Disclosed herein are compositions that are useful for targeting a signaling pathway modulator to a muscle cell. In some instances, such compositions may be useful in treating a muscle disorder, such as muscular dystrophy.
Claims13
An agent for selectively targeting muscle, the agent comprising (a) an antigen-binding domain comprising an antibody or antigen-binding portion thereof that selectively binds to a mammalian ITGA7 and (b) an IGF-1 polypeptide that is coupled to the antigen-binding domain.
Dependencies are inferred from the claim text.