Compositions and methods for suppressing intracellular synthesis of the beta subunit of human chorionic gonadotropin
AssigneeJames Summerton
InventorsJanet Helena Kinion, James E. Summerton
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Abstract
A composition of matter includes an antisense phosphorodiamidate morpholino oligomer (MO) that includes an MO base sequence. The MO base sequence includes at least the base sequence gcagcccctggaacat (SEQ ID NO: 8) and is arranged to bind a corresponding complementary base sequence of messenger RNA (mRNA) transcribed from one or more genes for the beta subunit of human chorionic gonadotropin (hCG-β). An inventive method, for suppressing intracellular synthesis of a beta subunit of human chorionic gonadotropin (hCG-β), includes introducing such an MO into one or more cells.
Claims20
A composition of matter comprising an antisense phosphorodiamidate morpholino oligomer (MO) that includes an MO base sequence, the MO base sequence including at least the base sequence gcagcccctggaacat (SEQ ID NO:
- 8) and being arranged to bind a corresponding complementary base sequence of messenger RNA (mRNA) transcribed from one or more genes for a beta subunit of human chorionic gonadotropin (hCG-β).
A method for suppressing intracellular synthesis of a beta subunit of human chorionic gonadotropin (hCG-β), the method comprising introducing into one or more cells an antisense phosphorodiamidate morpholino oligomer (MO) that includes an MO base sequence, the MO base sequence including at least the base sequence gcagcccctggaacat (SEQ ID NO:
- 8) and being arranged to bind a corresponding complementary base sequence of messenger RNA (mRNA) transcribed from one or more genes for the beta subunit of human chorionic gonadotropin (hCG-β).
Dependencies are inferred from the claim text.