T cell receptors recognizing R273C or Y220C mutations in P53
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSanghyun Kim, Nikolaos Zacharakis, Steven A. Rosenberg
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Abstract
Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R273C or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
Claims16
An isolated or purified nucleic acid comprising a nucleotide sequence encoding a T cell receptor (TCR) having antigenic specificity for a human p53R273C amino acid sequence, wherein the TCR comprises the amino acid sequences of
- all of SEQ ID NOs:
- 59-64.
An isolated or purified nucleic acid comprising a nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises the amino acid sequences of all of SEQ ID NOs:
- 59-64.
An isolated or purified nucleic acid comprising a nucleotide sequence encoding a protein comprising a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs:
- 59-61 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs:
- 62-64.
An isolated or purified nucleic acid comprising, from 5′ to 3′, a first nucleotide sequence and a second nucleotide sequence, wherein the first and second nucleotide sequence, respectively, encode the amino sequences of SEQ ID NOs:
- 65 and 66;
- 66 and 65;
- 67 and 68;
- 68 and 67;
- 69 and 70;
- 70 and 69;
- 69 and 68;
- 68 and 69;
- 133 and 70;
- 70 and 133;
- 133 and 134;
- 134 and 133;
- 65 and 132;
- 132 and 65;
- 131 and 66;
- 66 and 131;
- 131 and 132;
- 132 and 131;
- 71 and 72;
- 72 and 71;
- 73 and 74;
- 74 and 73;
- 75 and 76;
- or 76 and 75.
Dependencies are inferred from the claim text.