Immunogenic probiotic compositions and methods of use including in vaccination
AssigneeBiomEdit, Inc.
InventorsDharanesh Mahimapura Gangaiah, Arvind Kumar, Nallakannu Pillay Lakshmanan, Shrinivasrao Mane
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Abstract
The present invention provides probiotic compositions and methods for improving animal health, particularly improving and enhancing vaccine response. The probiotic compositions include one or more isolated strains of Lactobacillus species bacteria which colonizes the gastrointestinal tract to increase the health and enhance the immune system and immune response of an animal.
Claims31
A method of stimulating an immune response or increasing antibody titer to an infectious respiratory disease vaccine in a subject, said method comprising:
- administering an effective amount of an immunogenic probiotic composition comprising a combination of two Lactobacillus reuteri strains, wherein the first Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 49 or a sequence having at least 98% sequence identity with SEQ ID NO:
- 49, and wherein the second Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 44 or a sequence having at least 98% sequence identity with SEQ ID NO:
- 44, and an infectious respiratory disease vaccine to the subject.
A method of vaccinating a subject for an infectious respiratory disease or decreasing viral load of an infectious respiratory disease virus in a subject, said method comprising administering
- an effective amount of an immunogenic probiotic composition comprising a combination of two Lactobacillus reuteri strains wherein the first Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 49 or a sequence having at least 98%, sequence identity with SEQ ID NO:
- 49, and wherein the second Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 44 or a sequence having at least 98% sequence identity with SEQ ID NO:
- 44,and
- an infectious respiratory disease vaccine to a subject.
An immunogenic probiotic composition, said composition comprising a combination of two Lactobacillus reuteri strains, wherein the first Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 49 or a sequence having at least 98%, sequence identity with SEQ ID NO:
- 49, and wherein the second Lactobacillus reuteri strain comprises the genomic nucleic acid sequence SEQ ID NO:
- 44 or a sequence having at least 98% sequence identity with SEQ ID NO:
- 44, a pharmaceutically acceptable carrier, and an infectious respiratory disease vaccine.
Dependencies are inferred from the claim text.