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US 12,721,886 B2Granted
Virus-like particles containing CST1 protein and toxoplasma vaccine using same
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsFu-Shi Quan, Gi-Deok Eom, Hae-Ji Kang, Keon-Woong Yoon, Min-Ju Kim
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Abstract
Disclosed is a Toxoplasma gondii cyst wall protein cst1 (CST1)-containing influenza virus-like particle, which includes a core consisting of an influenza virus matrix protein 1 (M1); and the CST1 protein of Toxoplasma gondii displayed on a surface thereof; and a vaccine using the same.
Claims4
A Toxoplasma gondii cyst wall protein cst1 (CST1)-containing influenza virus-like particle, comprising:
- a core consisting of a influenza virus matrix protein 1 (M1);
- and
- an antigenic protein,
- wherein the antigen protein is the CST1 of Toxoplasma gondii, and
- the CST1 consists of the amino acid sequence of SEQ ID NO:
- 1.
3 more elements
A method for preparing a CST1-containing influenza virus-like particle, comprising:
- co-infecting an insect cell with i) a recombinant baculovirus expressing influenza virus matrix protein 1 (M1) and ii) a recombinant baculovirus expressing the CST1 of Toxoplasma gondii;
- and
- culturing the co-infected insect cell and purifying virus-like particles,
- wherein the CST1 consists of the amino acid sequence of SEQ ID NO:
- 1.
2 more elements
Dependencies are inferred from the claim text.