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US 12,721,862 B2Granted
Pharmaceutical composition for use in the treatment of cystitis of various etiologies
AssigneeFidia Farmaceutici S.P.A.
InventorsCarlo Pizzocaro, Anna Maria Zanellato, Mauro Pavan
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Abstract
A pharmaceutical sterile composition consisting of hyaluronic acid sodium salt and Hyaff11p50 and related use in the intravesical treatment of interstitial cystitis or Bladder Pain Syndrome (IC/BPS), of acute cystitis following bacterial infection, trauma or urolithiasis, of cystitis caused by radiation, chemotherapy, and hemorrhagic cystitis, as well as in the treatment of the bladder of patients undergoing endoscopic resection of benign or malignant bladder tumour at risk of relapse, are described.
Claims14
A pharmaceutical sterile composition comprising
- hyaluronic acid sodium salt;
- Hyaff11p50,
- wherein the hyaluronic acid sodium salt has a concentration equal to 1.8% w/w and the Hyaff11p50 has a concentration equal to 0.2% w/w, wherein Hyaff11p50 is a benzyl ester of hyaluronic acid with 50% of HA carboxyl groups esterified with hydroxy groups of benzyl alcohol;
- and
- optionally pharmacologically acceptable excipients-, wherein hyaluronic acid of both the hyaluronic acid sodium salt and the Hyaff11p50 has an average MW in the range between 160 and 260 kDa.
2 more elements
Dependencies are inferred from the claim text.