Double-stranded oligonucleotide targeting DKK1 gene, construct including same, and hair loss prevention or hair growth composition containing same

Abstract

A double-stranded oligonucleotide construct is described in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide for delivery of the double-stranded oligonucleotide into cells, as well as a nanoparticle produced by self-assembly of the double-stranded oligonucleotide construct via hydrophobic interaction in an aqueous solution, and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or nanoparticle, and effective to suppress the expression of DKK1 without side effects.

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