US 12,721,854 B2 · Inactivation of pathogens using metal-based coordination complexes, and methods and compositions for treating and preventing microbial and/or viral infections

Abstract

A method for eliciting an immune response in a patient includes the sequential steps of: providing an immunogenic composition including an immunogen; adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen; and administering the immunogenic composition to the patient so as to elicit the immune response against the immunogen. A method for preparing an attenuated immunogenic composition includes the steps of: providing an immunogenic composition including an immunogen; and adding a metal-based coordination complex to the immunogenic composition to inactivate or attenuate the immunogen in the immunogenic composition to provide the attenuated immunogenic composition.

Claims24

Dependent claims

A method for eliciting an immune response in a patient, said method comprising the sequential steps of:

adding a metal-based coordination complex to an immunogenic composition comprising an immunogen to prepare an inactivated immunogenic composition in which the immunogen is inactivated;
and
administering the inactivated immunogenic composition to the patient so as to elicit the immune response against the immunogen,
wherein the immunogen is a virus or an immunogenic viral component, and the metal-based coordination complex has the following structure:
including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof.

2 more elements

Dependencies are inferred from the claim text.

Inactivation of pathogens using metal-based coordination complexes, and methods and compositions for treating and preventing microbial and/or viral infections

Life of this patent

Inactivation of pathogens using metal-based coordination complexes, and methods and compositions for treating and preventing microbial and/or viral infections

Life of this patent

Abstract

Claims24