Pharmaceutical composition for preventing or treating graft versus host disease comprising thiamine derivatives
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsIn-Kyu Lee, Eun Jung Choi, Chang Hyun Jeon, Jae-Han Jeon
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Abstract
The present invention relates to a pharmaceutical composition for preventing, treating, or ameliorating graft versus host disease (GVHD), comprising thiamine derivatives, in which the active ingredient of the pharmaceutical composition is fursultiamine, which can alleviate weight loss found in patients with GVHD, reduce the infiltration of liver and colon inflammatory cells, and effectively inhibit the production of allogeneic CD4+ IFNγ+ T cells, and thus can be effectively used for the prevention, treatment, or amelioration of GVHD.
Claims8
A method for treating graft versus host disease (GVHD), comprising step of:
- administering a pharmaceutical composition comprising at least one compound selected from the group consisting of a thiamine derivative represented by chemical formula 1 below and a pharmaceutically acceptable salt thereof to a subject
- wherein R is any one selected from the group consisting of
A method for alleviating graft versus host disease (GVHD), comprising step of:
- administering a food composition comprising at least one compound selected from the group consisting of a thiamine derivative represented by chemical formula 1 below and a pharmaceutically acceptable salt thereof to a subject
- wherein R is any one selected from the group consisting of
Dependencies are inferred from the claim text.