Soft chewable veterinary dosage form

A Method for preparing a soft chewable veterinary dosage form comprising

• (a) fluralaner or a salt or solvate thereof;
• (b) a forming agent polyethylene glycol (PEG) that has a melting temperature between 30° C. and 80° C.,
• (c) a filler selected from starch such as corn starch, sucrose, lactose, dextrin, dextrate, mannitol, sorbitol, isomalt, glucose, fructose, soy grits, soy protein fines microcrystalline cellulose, silicified microcrystalline cellulose, silica, titan dioxide, kaolin, bentonite, calcium phosphate and mixtures thereof;
• (d) a liquid component comprising caprylic/capric triglyceride, dicaprylate/dicarprate, propylene glycol dicaprilyte/dicarprate, medium chain triglycerides, vegetable oil, glycerol, 2-pyrrolidone, dimethyl acetamide, polyethylene glycol and mixtures thereof;
• (e) one or more flavors, and
• (f) an aggregate comprising
• (f1) one or more physiologically active macrocyclic lactone(s),
• (f2) a binder
• (f3) a core material
• wherein the macrocyclic lactone is milbemycin oxime or moxidectin, the binder is polyethylene glycol and the core material is microcrystalline cellulose comprising the steps:
• (i) processing the binder (f2) and the physiologically active macrocyclic lactone (f1) with the core material (f3) to obtain the aggregate (f), wherein step (i) comprises the following sub-steps
• (i1) melt processing by heating the binder (f2) to an elevated temperature T1 between 25° C. and 80° C. and subsequently adding the physiologically active macrocyclic lactone (f1)
• (i2) adding the core material (f3) to the mixture from step (i1) or vice versa to form aggregate (f),
• (ii) blending the aggregate from step (i) with (a) fluralaner, (b) forming agent, (c) filler, (d) a liquid component and (e) flavor to obtain a dough,
• (iii) forming the dough from step (ii) to a soft chewable veterinary dosage form.