Compositions comprising selective androgen receptor modulator compounds in combination with weight loss drugs and uses thereof for quality weight loss

A method for maintenance or improvement of body composition compared to semaglutide monotherapy in a subject, comprising co-administering to the subject a composition comprising a pharmaceutical composition of Formula IX or an optical isomer, a racemic mixture, a pharmaceutically acceptable salt, a pharmaceutical product, a hydrate, an N-oxide, or a crystal thereof;

• and a pharmaceutical composition of semaglutide

A method for reducing or treating rebound in a subject in need thereof, wherein the rebound is in one or more of (i) weight gain, (ii) fat mass gain, and (iii) lean mass loss when the semaglutide is discontinued in said subject but Formula IX or an optical isomer, a racemic mixture, a pharmaceutically acceptable salt, a pharmaceutical product, a hydrate, an N-oxide, or a crystal thereof;

• treatment continues as monotherapy:
• wherein the subject was previously administered a composition comprising a pharmaceutical composition of Formula IX and a pharmaceutical composition of semaglutide.