Pharmaceutical liquid composition, kit of parts comprising the pharmaceutical liquid composition, and method for preparing the pharmaceutical liquid composition
AssigneeMperium B.V.
InventorPeter Meijlink
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Abstract
A pharmaceutical liquid composition includes a solution of a physiologically acceptable salt of 4-phenylbutyric acid, which in one embodiment is the sodium salt of 4-phenylbutyric acid, in an aqueous medium at a concentration of at least 1.34 mmol/ml. The aqueous medium includes glycerol; a viscosity enhancing agent, where the viscosity enhancing agent includes a cellulose derivate, and water. The pharmaceutical liquid composition further includes a sweetening agent.
Claims23
A pharmaceutical liquid composition comprising a solution of a physiologically acceptable salt of 4-phenylbutyric acid, in an aqueous medium at a concentration of at least 1.34 mmol/ml and pH>8;
- wherein the aqueous medium comprises:
- a. glycerol, having a volume concentration of at least 1.0 ml/l relative to the total volume of the aqueous medium;
- b. a viscosity enhancing agent, wherein the viscosity enhancing agent comprises hydroxyethylcellulose as the only cellulose derivate;
- and
- c. water;
- and
- wherein the pharmaceutical liquid composition further comprises a sweetening agent,
- wherein the sweetening agent comprises a natural sweetening agent and/or an artificial sweetening agent, wherein the natural sweetener is selected from the group consisting of sucrose, dextrose, fructose, sorbitol, xylitol, vanilla, mannitol and mixtures thereof and wherein the artificial sweetener is selected from the group consisting of sodium saccharine, sodium cyclamate, aspartame, lacititol, isomalt, sucralose acesulfame K, neohespiridine, sucralose and mixtures thereof, and
- wherein the weight ratio between the glycerol and the viscosity enhancing agent is between 200:1 and 10:1.
Dependencies are inferred from the claim text.