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US 12,721,800 B2Granted
Phosphonates and N-halamines compositions for tartar removal
AssigneesO.Y.M. Innovation Ltd., Bar-Ilan University
InventorsShlomo Margel, Hanna Steinmetz, Chen Gelber, Yarden Goldstein
Life of this patent
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Abstract
Provided herein are compositions and methods comprising phosphonates, N-halamines or combination thereof for dental care. Specifically, for removing tartar (calculus), including mature tartar.
Claims24
A dental care composition comprising at least one tetra-phosphonate compound or salt thereof, in an amount of 0.05%-30% by weight of said composition;
- wherein the at least one tetra-phosphonate compound is represented by the following structure:
- wherein,
- L is alkyl, alkylaryl, alkynyl, aryl, alkyl ether, alkyl thioether, alkyl amide, alkyl amine, or an amino side chain;
- wherein the side chain of the amino acid is attached to the carbon;
- and
- wherein said alkyl, alkylaryl, alkynyl, aryl, alkyl ether, alkyl thioether, alkyl amide, alkyl amine, or an amino side chain are each substituted or unsubstituted;
- and a pharmaceutically acceptable carrier.
4 more elements
A method for removing mature tartar from the tooth surface of a subject by administering a composition comprising at least one poly-phosphonate or salt thereof, in an amount of 0.05%-30% by weight of said composition;
- and a pharmaceutically acceptable carrier, wherein the poly-phosphonate compound is a bisphosphonate compound represented by the following structure or salt thereof:
- or the poly-phosphonate is tetra-phosphonate compound represented by the following structure or salt thereof
- wherein,
- L is alkyl, alkylaryl, alkynyl, aryl, alkyl ether, alkyl thioether, alkyl amide, alkyl amine, or an amino side chain;
- wherein the side chain of the amino acid is attached to the carbon;
- and
- wherein said alkyl, alkylaryl, alkynyl, aryl, alkyl ether, alkyl thioether, alkyl amide, alkyl amine, or an amino side chain are each substituted or unsubstituted.
4 more elements
Dependencies are inferred from the claim text.