Systems and approaches for drug delivery
AssigneesAmgen Inc., Amgen Research (Munich) GmbH
InventorsCornelius Pompe, Nicholas J. Clark, Wei Qi, Arnold J. McAuley, Michael Schneider, Chia-Jung Wu, Twinkle R. Christian, Heather N. Franey, Bharadwaj Jagannathan, Jeffrey Abel, Franz Dietzel
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Abstract
An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.
Claims4
A method of determining material compatibility for components of a drug delivery system, including using a surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system, wherein the at least one material comprises a first potential material, the method further comprising the steps of:
- providing a double gap flow cell having a top layer, a bottom layer, and a flow path for the desired molecule to flow therebetween in the given IV-bag system, the top and bottom layers being constructed from the first potential material;
- measuring a first zeta-potential of the given IV-bag system when the desired molecule flows through the first potential material of the top layer and the first potential material of the bottom layer.
Dependencies are inferred from the claim text.