Use of evoked potentials in deep brain stimulation neuromodulation
AssigneeBoston Scientific Neuromodulation Corporation
InventorsG. Karl Steinke, Mahsa Malekmohammadi
Life of this patent
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Abstract
Methods and systems for providing deep brain stimulation (DBS) for a patient are described. Electrical stimulation is provided to a patient's brain and evoked potentials (EPs) are recorded at two or more electrodes. The EPs evoked and/or recorded at different electrodes are used to estimate if the respective electrodes are located in the same or different anatomical brain regions. The EPs may also be used to predict or suggest appropriate stimulation rates for therapeutic stimulation.
Claims20
A method of estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the method comprising:
- using one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
- using at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
- comparing the first EPs and the second EPs to determine a delay between the EPs wherein the delay is indicative a difference in a number or kind of synapses between a first neural circuit giving rise to the first EP and a second neural circuit giving rise to the second EP;
- and
- using the comparison to estimate a location of the electrode lead within the patient's brain.
A system for estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the system comprising:
- control circuitry configured to:
- use one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
- use at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
- compare the first EPs and the second EPs to determine a delay between the EPs wherein the delay is indicative a difference in a number or kind of synapses between a first neural circuit giving rise to the first EP and a second neural circuit giving rise to the second EP;
- and
- use the comparison to estimate a location of the electrode lead within the patient's brain.
A method of estimating a position of an electrode lead within a patient's brain, wherein the electrode lead comprises a plurality of electrodes, the method comprising:
- using one or more of the plurality of electrodes to provide active stimulation to the patient's brain;
- using at least a first of the plurality of electrodes to record first evoked potentials (EPs) evoked by the active stimulation and a second of the plurality of electrodes to record second EPs evoked by the active stimulation;
- comparing the first EPs and the second EPs to determine if the first and second electrodes are concurrently in different anatomical brain structures;
- and
- using the comparison to estimate a location of the electrode lead within the patient's brain.
Dependencies are inferred from the claim text.