US 12,721,537 B2 · System and method for measuring blood flow velocity on a microfluidic chip

Abstract

This application describes a microfluidic system for measuring blood flow velocity using particle image velocimetry (PIV) and wavelet-based optical flow velocimetry (wOFV) processing to determine one or more hemodynamic parameters. The hemodynamic parameters can include whole blood rheology as well as spatiotemporal variations in blood velocity, respectively, during coagulation in flowing blood samples. The system can provide quantitative information on the formation and evolution of thrombi, identify subjects with clotting disorders associated with abnormal thrombus growth rate, and/or determine the effect of therapeutics and/or therapeutical approaches on clotting dynamics and thrombus formation.

Claims19

Dependent claims

A system comprising:

a microfluidic device having at least one microchannel through which a blood sample flows;
a camera configured to obtain a plurality of images of the blood sample flowing through the microchannel;
and
a processor configured to determine one or more hemodynamic parameters based on differences between two sets of consecutive images of the plurality of images, wherein the processor uses particle image velocimetry (PIV) of a first set of consecutive images to determine temporal evolution of mean blood flow velocity and wavelet-based optical flow velocimetry (wOFV) of a second set of consecutive images to determine a blood flow velocity field, and
wherein the processor is configured to identify blood flow channels around thrombi formed in the microchannel by the blood flow velocity field generated by wOFV.

2 more elements

Dependencies are inferred from the claim text.

System and method for measuring blood flow velocity on a microfluidic chip

Life of this patent

System and method for measuring blood flow velocity on a microfluidic chip

Life of this patent

Abstract

Claims19