RF amplitude auto-calibration for mass spectrometry

A system comprising:

• a mass spectrometer comprising an RF gain block, a peak detector, and a controller, the system being operable to:
• apply a DC voltage to the RF gain block using the controller;
• measure a DC calibration voltage using the peak detector;
• apply an RF voltage to the RF gain block using the controller;
• measure an RF calibration voltage;
• calculate an RF calibration factor based on the measured calibration voltages using the controller;
• and
• during operation, apply a combined RF and DC RF signal to the RF gain block based on the RF calibration factor.

A method for mass spectrometry, the method comprising:

• in a mass spectrometer comprising a coil, a peak detector, and a controller:
• applying a DC voltage to the RF gain block using the controller;
• measuring a DC calibration voltage using the peak detector;
• applying an RF voltage to the coil using the controller;
• measuring an RF calibration voltage;
• calculating an RF calibration factor based on the measured calibration voltages using the controller;
• and
• during operation, applying an RF signal to the coil based on the RF calibration factor and summing one or more additional DC voltages to the RF signal.