Copper-64 compositions and formulations
AssigneeCurium US LLC
InventorsBrian Regna, Allan Casciola, Lauren Radford, Shaun Loveless, David Pipes, William Uhland, Craig Brunkhorst
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Abstract
The present disclosure is directed compositions and formulations comprising high levels of copper-64, and process for preparing said compositions and formulations. The present disclosure also relates to methods of administering copper-64 compositions to a patient in need thereof.
Claims30
A composition suitable for use to a patient in need thereof comprising from 35 MBq to 150 MBq of copper-64 (64Cu) per 1 mL of the composition, wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET), and
- (a) from 4.94×10−7 μCi of cobalt-55 (55Co)/ml of the composition to 2.82×10−4 μCi of 55Co/ml of the composition;
- (b) from 4.10×10−7 μCi of cobalt-57 (57Co)/ml of the composition to 5.21×10−4 μCi of 57Co/ml of the composition;
- (c) from 3.79×10−9 μCi of cobalt-61 (61Co)/ml of the composition to 2.02×10−5 μCi of 61Co/ml of the composition;
- (d) from 4.62×10−7 μCi of copper-61 (61Cu)/ml of the composition to 4.44×10−4 μCi of 61Cu/ml of the composition;
- or
- (e) from 1.85×10−17 μCi of copper-60 (60Cu)/ml of the composition to 2.54×10−14 μCi of 60Cu/ml of the composition.
A method comprising administering to a patient in need thereof a composition comprising from 35 MBq to 150 MBq of copper-64 (64Cu) per 1 mL of the composition, wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET), and
- (a) from 4.94×10−7 μCi of cobalt-55 (55Co)/ml of the composition to 2.82×10−4 μCi of 55Co/ml of the composition;
- (b) from 4.10×10−7 μCi of cobalt-57 (57Co)/ml of the composition to 5.21×10−4 μCi of 57Co/ml of the composition;
- (c) from 3.79×10−9 μCi of cobalt-61 (61Co)/ml of the composition to 2.02×10−5 μCi of 61Co/ml of the composition;
- (d) from 4.62×10−7 μCi of copper-61 (61Cu)/ml of the composition to 4.44×10−4 μCi of 61Cu/ml of the composition;
- or
- (e) from 1.85×10−17 μCi of copper-60 (60Cu)/ml of the composition to 2.54×10−14 μCi of 60Cu/ml of the composition.
Dependencies are inferred from the claim text.