Materials and methods for detecting and treating autoimmune movement disorders
AssigneeMayo Foundation for Medical Education and Research
InventorsAnastasia Zekeridou, Andrew McKeon
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Abstract
Materials and methods are provided herein for detecting the presence of an autoantibody specific for PDE10A to identify the mammal as having an autoimmune neurological disorder as well as methods and materials for treating an autoimmune neurological disorder. Materials and methods also are provided herein for treating cancer and/or neurological autoimmunity in a mammal using an immune checkpoint inhibitor and detecting the presence of an autoantibody specific for PDE10A to monitor for the development of neurologic complications in the mammal.
Claims5
A method for treating a mammal having a paraneoplastic movement disorder, wherein said method comprises:
- (a) detecting the presence of an autoantibody specific for phosphodiesterase 10A (PDE10A) in a sample obtained from said mammal, and
- (b) administering a steroid to said mammal.
A method for treating a paraneoplastic movement disorder in a mammal having an autoantibody specific for phosphodiesterase 10A (PDE10A), wherein said method comprises:
- administering, to said mammal, a steroid.
Dependencies are inferred from the claim text.