Biomarkers for the diagnosis of atrial fibrillation cause of stroke
AssigneeIschemia Care LLC
InventorJeffrey Gerard June
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Abstract
This invention provides gene expression profiles useful for diagnosing atrial fibrillation in ischemic stroke and for distinguishing atrial fibrillation in ischemic stroke from arterial (large vessel) stroke or embolic stroke of undetermined source (ESUS). In another aspect, the present invention is the provision of an improved method for prognosis of an outcome or assessing the risk of a patient having suffered a stroke or a transient ischemic attack, comprising determining the level of expression of at least one biomarker in a sample of the patient.
Claims13
A method for diagnosing the occurrence of atrial fibrillation in ischemic stroke or a predisposition for experiencing atrial fibrillation in ischemic stroke in a human subject, the method comprising:
- determining a level of mRNA expression of a plurality of atrial fibrillation in ischemic stroke-associated biomarkers in a biological sample from the subject, wherein the biomarkers are selected from the group consisting of:
- ELL2, GLIPR1, and MAPKAPK3;
- comparing the level of expression of the atrial fibrillation in ischemic stroke-associated biomarkers to the expression level of a stably expressed endogenous reference biomarker, wherein the stably expressed endogenous reference biomarker is selected from the group consisting of:
- USP7, MAPRE2, CSNK1G2, SAFB2, PRKAR2A, PI4 KB, CRTC1, HADHA, MAP1LC3B, KATS, GTSE1, CDC2L1 or CDC2L2, TCF25, CHP, LRRC40, hCG 2003956 or LYPLA2 or LYPLA2P1, DAXX, UBE2NL, EIF1, KCMF1, PRKRIP1, CHMP4A, TMEM184C, TINF2, PODNL1, FBXO42, LOC441258, RRP1, C10orf104, ZDHHCS, C9orf23, LRRC45, NACC1, LOC100133445 or LOC115110, and PEX16;
- detecting that the expression level of one or more of the atrial fibrillation in ischemic stroke-associated biomarkers is increased as compared to the expression level of the stably expressed endogenous reference biomarker;
- diagnosing the occurrence of, or the predisposition for experiencing, atrial fibrillation in ischemic stroke in the subject;
- and
- administering an anticoagulant therapy to the subject.
Dependencies are inferred from the claim text.