Treatment of disc degenerative disease and stimulation of proteoglycan synthesis by fibroblast conditioned media and formulations thereof
AssigneeFibrobiologics, Inc.
InventorsPete O'Heeron, Thomas Ichim
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Abstract
In some aspects, disclosed are methods and compositions for disc regeneration and/or repair using one or more components from conditioned media from fibroblasts. In certain cases, conditioned media is obtained from fibroblasts stimulated with one or more opioid receptor antagonists and one or more toll-like receptor agonists. Conditioned media from fibroblasts may be provided in an effective amount to an individual in need thereof.
Claims8
A method of promoting disc regeneration in an individual, the method comprising providing to the individual an effective amount of fibroblast cells previously cultured with one or more opioid receptor antagonists and one or more toll-like receptor (TLR) agonists.
Dependencies are inferred from the claim text.