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US 12,715,937 B2Granted
Bi-specific fusion proteins
AssigneeSilver Creek Pharmaceuticals, Inc.
InventorsUlrik Bjerl Nielsen, Thomas Wickham, Birgit Schoeberl, Brian Harms, Bryan Linggi, Matthew Onsum, Byron DeLaBarre
Life of this patent
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Abstract
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.
Claims2
A bi-specific fusion protein comprising:
- (a) a targeting domain of anti-DNA scFv selected from the group of SEQ ID NOs:
- 1 and 2;
- and
- (b) an activator domain of insulin-like growth factor 1.
1 more element
Dependencies are inferred from the claim text.