Humanized single-domain antibodies binding to epitope tags
AssigneeNano Tag Biotechnologies GmbH
InventorsJan Patrick Bogen, Joycelyn Wüstehube-Lausch, Hans-Ulrich Schmoldt
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Abstract
The present invention provides humanized versions of single-domain antibodies specifically binding the epitope tag of SRLEEELRRRLTE (SEQ ID NO: 2), which can be used for binding, detection, immobilization, isolation or purification a protein comprising the said epitope tag. Furthermore, the present invention relates to a nucleic acid encoding the humanized antibody and a vector comprising the nucleic acid, as well as a host cell comprising the nucleic acid or the vector described herein.
Claims17
A humanized single-domain antibody that specifically binds to an epitope tag comprising the sequence SRLEEELRRRLTE (SEQ ID NO:
- 2), wherein the antibody comprises the amino acid sequence of SEQ ID NO:
- 119, SEQ ID NO:
- 120, SEQ ID NO:
- 121, SEQ ID NO:
- 122, SEQ ID NO:
- 123, SEQ ID NO:
- 124, or SEQ ID NO:
- 125.
Dependencies are inferred from the claim text.