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US 12,715,934 B2Granted
Anti-idiotype antibody molecules and uses thereof
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorSusan Sloan
Life of this patent
Estimating the term…
Abstract
Antibody molecules that specifically bind to anti-APRIL antibody are disclosed. The antibody molecules can be used in assays for detecting anti-APRIL antibodies.
Claims23
An antibody molecule capable of binding to an anti-APRIL antibody, comprising:
- (a) a heavy chain variable region (VH) comprising
- (i) an HCDR1 comprising the amino acid sequence of SEQ ID NO:
- 11,
- (ii) an HCDR2 comprising the amino acid sequence of SEQ ID NO:
- 12, and
- (iii) an HCDR3 comprising the amino acid sequence of SEQ ID NO:
- 13;
- and
- (b) a light chain variable region (VL) comprising
- (iv) an LCDR1 comprising the amino acid sequence of SEQ ID NO:
- 14,
- (v) an LCDR2 comprising the amino acid sequence AAS, and
- (vi) an LCDR3 comprising the amino acid sequence of SEQ ID NO:
- 16.
11 more elements
Dependencies are inferred from the claim text.