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US 12,715,924 B2Granted
Method of treating ichthyosis in a subject by administering an anti-interleukin 36 receptor (IL-36R) binding agent
AssigneeAnaptysBio, Inc.
InventorsAmy Paller, Emma Guttman, Irina Khanskaya, Rupal Kalapanda, Marco Londei
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Abstract
The invention relates to methods of treating ichthyosis in a subject with an inhibitor of the interleukin 36 (IL-36) pathway, and methods of selecting a subject for therapy with the IL-36 pathway inhibitor.
Claims14
A method of treating ichthyosis in a subject, the method comprising administering to the subject an IL-36R-binding agent that comprises a heavy chain comprising:
- a HCDR1 of SEQ ID NO:
- 65, a HCDR2 of SEQ ID NO:
- 71, and HCDR3 of SEQ ID No:
- 72;
- and a light chain polypeptide comprising:
- or at least a LCDR1 of SEQ ID NO:
- 83, LCDR2 of SEQ ID NO:
- 84, and LCDR3 of SEQ ID NO:
- 85.
6 more elements
Dependencies are inferred from the claim text.