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US 12,715,922 B2Granted
Anti-Galectin-9 antibodies and uses thereof
AssigneesNew York University, PureTech LYT, Inc.
InventorsShohei Koide, George Miller, Akiko Koide, Linxiao Chen, Aleksandra Filipovic, Eric Elenko, Joseph Bolen
Life of this patent
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Abstract
Disclosed herein are anti-Galectin-9 antibodies and methods of using in modulating (e.g., increasing) immune responses in a subject, either taken alone or in combination with an immune checkpoint inhibitor, such as a PD-1 inhibitor.
Claims15
An isolated antibody, which binds human galectin-9, wherein the antibody comprises (a) a heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region, and (b) a light chain comprising a light chain variable region (VL) and a light chain constant region;
- wherein the VH comprises a heavy chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO:
- 22, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO:
- 23, and a heavy chain complementary determining region 3 (CDR3) set forth as SEQ ID NO:
- 24,
- wherein the VL comprises a light chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO:
- 19, a light chain complementary determining region 2 (CDR2) set forth as SEQ ID NO:
- 20, and a light chain complementary determining region 3 (CDR3) set forth as SEQ ID NO:
- 21,
- wherein the heavy chain constant region comprises the amino acid sequence of SEQ ID NO:
- 36, and
- wherein the light chain constant region comprises the amino acid sequence of SEQ ID NO:
- 37.
9 more elements
Dependencies are inferred from the claim text.