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AssigneeGenentech, Inc.
InventorsJames Thomas Koerber, Alejandra Beatrice Urpi Urrutia, Simon-Peter Williams, Christopher Williamson Davies, Shravan Kumar Sriraman, Herman Singh Gill, James Richard Kiefer, Jr.
Estimating the term…
Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.
A CD8 binding agent comprising a variable domain of the heavy chain of a heavy chain antibody (VHH domain) wherein the VHH comprises a CDR1 comprising an amino acid sequence of SEQ ID NO:6 or SEQ ID NO:7;
The CD8 binding agent of 20, wherein the metal is aluminum and the radionuclide is 18F.
Dependencies are inferred from the claim text.