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US 12,715,919 B2Granted
Anti-CD3 antibody and molecules comprising the antibody
AssigneeDaiichi Sankyo Company, Limited
InventorsTohru Takahashi, Chigusa Yoshimura, Shiho Kozuma, Kensuke Nakamura, Chikako Suzuki, Junya Ichikawa
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Abstract
The present invention provides a novel antibody binding to human CD3, and a molecule having antigen binding activity that includes the antibody. The present invention provides a novel antibody binding to human CD3, a molecule having antigen binding activity that includes the antibody, and a pharmaceutical composition having cytotoxic activity that includes the antibody or the molecule as an active ingredient.
Claims46
An anti-CD3 scFv, comprising:
- a heavy chain variable sequence comprising
- CDRH1 comprising SEQ ID NO:
- 26,
- CDRH2 comprising SEQ ID NO:
- 98, wherein the first Xaa is selected from the group consisting of R and S, and the second Xaa is S, and
- CDRH3 comprising SEQ ID NO:
- 28;
- and
- a light chain variable sequence comprising
- CDRL1 comprising SEQ ID NO:
- 29,
- CDRL2 comprising SEQ ID NO:
- 99, wherein Xaa is selected from the group consisting of Q, A, G, S, N, and D, and
- CDRL3 comprising SEQ ID NO:
- 31.
12 more elements
An scFv comprising:
- a heavy chain variable region comprising SEQ ID NO:
- 100, wherein the first Xaa is selected from the group consisting of R and S, and the second Xaa is S;
- and
- a light chain variable region comprising any one of SEQ ID NOs:
- 101, 102, and 103, wherein Xaa is selected from the group consisting of Q, A, G, S, N, and D.
2 more elements
A molecule comprising an scFv comprising:
- a heavy chain variable region comprising SEQ ID NO:
- 100, wherein the first Xaa is selected from the group consisting of R and S, and the second Xaa is S;
- and
- a light chain variable region comprising any one of SEQ ID NOs:
- 101, 102, and 103, wherein Xaa is selected from the group consisting of Q, A, G, S, N, and D;
- wherein the scFv binds to human CD3 and to cynomolgus monkey CD3.
3 more elements
Dependencies are inferred from the claim text.