Rapid elicitation of broadly neutralizing bovine antibodies to HIV Env
AssigneesInternational AIDS Vaccine Initiative, The Scripps Research Institute, The Texas A&M University System
InventorsDevin Sok, Dennis R. Burton, Vaughn V. Smider, Ian Wilson, Michael Criscitiello, Waithaka Mwangi
Life of this patent
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Abstract
The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab′)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.
Claims18
An isolated monoclonal antibody that specifically binds to Env and comprises a VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3 comprising the amino acid sequence of
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Dependencies are inferred from the claim text.