TGF-beta RII mutant and fusion protein thereof

Abstract

In view of the technical problem that TGF-β RII and a fusion protein thereof are prone to degradation and breakage during the process of recombinant expression, provided are a TGF-β RII mutant and a fusion protein thereof. Compared with the extracellular region of the wild-type TGF-β RII of SEQ ID NO: 6, the TGF-β RII mutant has a mutation selected from Gln at position 6, Asp at position 12 and Gly at position 20. The TGF-β RII mutant is capable of binding to TGF-β. Compared to wild-type TGF-β RII, the TGF-β RII mutant has less breakage and/or degradation during recombination expression. It is convenient for large-scale production of antibodies/the TGF-β RII bifunctional protein with a more stable quality.

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