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US 12,715,903 B2Granted
Multimeric proteins for detecting a carbohydrate and/or treating a siglec-mediated disorder
AssigneePalleon Pharmaceuticals Inc.
InventorsLi Peng, Adam Petrone, Lihui Xu, Adam Shoemaker
Life of this patent
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Abstract
The invention relates generally to polypeptides comprising a lectin domain, multimeric proteins comprising the polypeptides, and use of the polypeptides or multimeric proteins in the detection of a carbohydrate (e.g., a sialic acid containing carbohydrate or Siglec ligand) or the treatment of a Siglec-mediated disorder.
Claims4
An isolated polypeptide comprising:
- a) a lectin domain comprising a Sialic acid-binding immunoglobulin-type lectin (Siglec) sialic acid binding V-set immunoglobulin-like domain of Siglec-7 or Siglec-9, or a variant thereof;
- b) a trimerization domain;
- and
- c) a dimerization domain,
- wherein the lectin domain, the trimerization domain, and the dimerization domain are covalently linked together in an N- to C-terminal orientation;
- and
- wherein the polypeptide comprises SEQ ID NO:
- 7, SEQ ID NO:
- 8, or amino acids 20-610 of SEQ ID NO:
- 67.
7 more elements
Dependencies are inferred from the claim text.