US 12,715,899 B2 · Pharmaceutical composition for lowering blood cholesterol, preventing or treating cardiovascular diseases and reducing inflammation

Abstract

The present invention relates to a pharmaceutical composition and the like for lowering blood cholesterol, preventing or treating cardiovascular diseases and reducing inflammation, containing, as an active ingredient, an inhibitor of binding between CAP1 and PCSK9, an inhibitor of binding between CAP1 and resistin, or a CAP1 gene expression inhibitor. The present invention can lower the level of blood LDL-cholesterol by inhibiting the binding of CAP1 and PCSK9, the binding of CAP1 and resistin or the expression of a CAP1 gene. Therefore, the present invention can be effectively used as a pharmaceutical composition and the like for treating abnormal blood cholesterol levels and various cardiovascular diseases caused thereby, such as dyslipidemia, stroke, arteriosclerosis, and the like, and for inhibiting inflammation.

Claims8

Dependent claims

A method for lowering blood cholesterol comprising administering to a subject in need thereof, a composition comprising,

an inhibitor of binding between adenylyl cyclase-associated protein 1 (CAP1) and proprotein convertase subtilisin or kexin type-9 (PCSK9),
wherein the inhibitor is selected from SEQ ID NO:
4 and SEQ ID NO:
6, and
wherein the inhibitor specifically binds to one or more domains selected from the group consisting of a Src homolog 3 (SH3) binding domain of CAP1 and a cysteine-rich domain (CRD) of PCSK9.

2 more elements

Dependencies are inferred from the claim text.

Pharmaceutical composition for lowering blood cholesterol, preventing or treating cardiovascular diseases and reducing inflammation

Life of this patent

Pharmaceutical composition for lowering blood cholesterol, preventing or treating cardiovascular diseases and reducing inflammation

Life of this patent

Abstract

Claims8