Oxysterol compounds and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

• wherein:
• is a single or double bond;
• R1 is hydrogen or —OH;
• R2, R3, R4, and R5 are hydrogen;
• R6 is C6-C10aryl or C2-C9heteroaryl, wherein C6-C10aryl or C2-C9heteroaryl are optionally substituted with 1, 2, 3, or 4 R7 groups;
• each R7 is independently selected from deuterium, halogen, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, C2-9heteroaryl, —OR8, —SR8, —N(R9)(R10), —C(O)OR9, —C(O)N(R9)(R10), —C(O)R11, —S(O)2R11, and —S(O)2N(R9)(R10), wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C2-9heteroaryl are optionally substituted with one, two, or three groups independently selected from halogen, oxo, —CN, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, —OR8, —SR8, —N(R9)(R10), —C(O)OR9, —C(O)N(R9)(R10), —C(O)R11, —S(O)2R11, and —S(O)2N(R9)(R10);
• each R8 is independently selected from H, C1-6alkyl, C1-6haloalkyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl;
• each R9 and each R10 are each independently selected from H, C1-6alkyl, C1-6haloalkyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl;
• and
• each R11 is independently selected from C1-6alkyl, C1-6haloalkyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl.