Chiral synthons for the synthesis of chiral phosphorothioates

A compound of formula (I)

• wherein
• n is 0, 1, 2, 3, 4, 5, or 6;
• each X is selected from the group consisting of a bond;
• —(CH2)m— optionally substituted with halogen, —CN, C1-3alkyl or —O—C1-3alkyl;
• O;
• NRN and S;
• wherein m is 1, 2, 3 or 4, and RN is H or C1-3alkyl;
• R1 is selected from the group consisting of H, C1-6alkyl, C3-6cycloalkyl, —CH2-C3-10cycloalkyl, aryl, —CH2-aryl, and heteroaryl,
• wherein each aryl and heteroaryl group is optionally substituted with 1-3 substituents selected from the group consisting of halogen, —CN, C1-3alkyl and —O—C1-3alkyl;
• R2 is selected from the group consisting of C1-4alkyl, —C(O)OR6, and aryl,
• wherein each alkyl group of R2 is optionally substituted with halogen, cyano, or trimethylsilyl, and wherein R6 is a C1-4alkyl;
• R3 is selected from the group consisting of H, C1-6alkyl, C3-6cycloalkyl,—CH2—C3-10cycloalkyl, aryl, —CH2-aryl, and heteroaryl,
• wherein each aryl and heteroaryl group is optionally substituted with 1-3 substituents selected from the group consisting of halogen,—CN, C1-3alkyl and —O—C1-3alkyl;
• and
• R4 and R5 are each independently of each other selected from the group consisting of H, C1-6alkyl, C3-6cycloalkyl, —CH2—C3-10cycloalkyl, aryl, —CH2-aryl, and heteroaryl,
• wherein each aryl and heteroaryl group is optionally substituted with 1-3 substituents selected from the group consisting of halogen,—CN, C1-3alkyl and —O-C1-3alkyl;
• or a tautomer, stereoisomer or salt thereof.