Cyclic compounds and methods of using same
AssigneeSchrödinger, Inc.
InventorsSayan Mondal, Haifeng Tang, Xianhai Huang, Adam Marc Levinson, Leah Frye, Sathesh Bhat, Pieter Harm Bos, Zef Konst, Phani Ghanakota, Jeremy Robert Greenwood
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Abstract
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
Claims94
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is hydrogen or halogen;
- R2 is a 5-6 membered heteroaryl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen and C1-C6 alkyl;
- or a 5-6 membered heterocyclyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen and C1-C6 alkyl;
- R3 is hydrogen or C1-C6 alkyl;
- Ring A is a C6-C10 cycloalkyl or a 6-10 membered heterocyclyl;
- each R4 is independently selected from the group consisting of halogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, C1-C6 alkoxy (C1-C6 alkyl)-, —C(═O) C1-C6 alkyl, C2-C6 alkynyl, C3-C6 cycloalkyl, —NRARB, and 4-6 membered heterocyclyl optionally substituted with 1 or 2 independently selected halogen;
- each RA and RB is independently hydrogen or C1-C6 alkyl;
- and
- m is 0, 1, 2, 3, or 4.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.