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US 12,715,871 B2Granted
Aromatic ring-lactam compound, preparation method therefor and use thereof
AssigneeShanghai Ringene Biopharma Co., Ltd.
InventorsHuixin Wan, Chuantao Zha, Jingui Ma, Jingkang Shen
Life of this patent
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Abstract
Provided are an aromatic ring-lactam compound as shown in formula (I), and a preparation method therefor and the use thereof. The aromatic ring-lactam compound has a novel structure, has good inhibitory activity on ERK1/2 kinases, can inhibit the proliferation of tumor cells, and has anti-tumor activity.
Claims17
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,
- in the formula,
- R1 is independently selected from substituted 3 to 8 membered cycloalkyl, unsubstituted 3- to 8-membered heterocycloalkyl and substituted 5-to 10-membered heteroaryl;
- the substituent is independently selected from halogen, hydroxyl or C1-C8 alkyl;
- R2a and R2b are independently hydrogen;
- R3a and R3b are independently selected from hydrogen and unsubstituted C1-C6 alkyl;
- R4a and R4b are independently selected from hydrogen and substituted or unsubstituted C1-C6 alkyl;
- the substituent is independently selected from hydroxyl and amino;
- Ar is selected from any one of the following substituted or unsubstituted groups:
- 5-to 10- membered aryl or 5-to 10-membered heteroaryl;
- the substituent is independently selected from one or more than one halogen, C1-C6 alkyl, deuterated C1-C6 alkoxy, C1-C6 alkoxy, C1-C6 alkylamino;
- M is selected from N or CR5;
- R5 is halogen;
- M1 and M2 are each independently selected from N and CR6;
- R6 is independently selected from hydrogen, halogen and C1-C6 alkyl;
- X and Y are each CH;
- wherein, the heteroaryl contains 1 to 3 heteroatoms selected from the following group:
- N and O, and the heterocycloalkyl contains 1 to 3 heteroatoms selected from following group:
- N and O, each ring system is independently saturated or unsaturated monocyclic ring.
15 more elements
Dependencies are inferred from the claim text.