Back to results
US 12,715,864 B2Granted
Process for the synthesis of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide
AssigneeVicore Pharma AB
InventorsDmitrijs Cernaks, Eliza Dege
Life of this patent
Estimating the term…
Abstract
There is provided a new process for the synthesis of compounds of formula I, which are useful as angiotensin (Ang II) type 2 receptor agonists: by reacting a compound of formula II, with an excess of a compound of formula III, wherein W, Z and X have meanings given in the description; followed by reaction of the intermediate so formed with a suitable source of the counter-ion, W.
Claims10
A process for the preparation of a compound of formula I,
- wherein R represents C1-6 alkyl, optionally substituted by one or more halo groups, and W represents a base addition salt counter-ion, which process comprises:
- (a) reaction of a compound of formula II,
- wherein Z represents an acid addition salt counter-ion, with an excess of a compound of formula III,
- wherein X represents a suitable leaving group and R is as defined above;
- followed by
- (b) reaction of the compound of formula IV,
- so formed with a suitable base to provide W, as defined above.
4 more elements
Dependencies are inferred from the claim text.