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US 12,715,859 B2Granted
Pyrazole-substituted cyclopentanol ester derivative and use thereof
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsYinsheng Zhang, Yong Gao, Bin Cao, Jinan Wang, Damin Zhao
Life of this patent
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Abstract
The present application relates to a pyrazole-substituted cyclopentanol ester derivative and use thereof, and in particular to a compound represented by formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.
Claims18
A compound of formula (II), or a pharmaceutically acceptable salt thereof,
- wherein,
- ring A is a benzene ring fused to a 5-6 membered heteroalkyl ring, wherein the benzene ring fused to the 5-6 membered heteroalkyl ring is optionally substituted with 1, 2 or 3 Ra;
- L1 and L2 are each independently selected from the group consisting of a single bond;
- R1 is selected from the group consisting of H and C1-3 alkyl;
- wherein the C1-3 alkyl is optionally independently substituted with 1, 2 or 3 Rd;
- Ra is each independently selected from the group consisting of halogen, OH, CN, NH2, ═O, C1-3 alkyl and C1-3 alkoxy, and the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1, 2 or 3 Rx;
- Rb is each independently selected from the group consisting of H and C1-3 alkyl;
- the C1-3 alkyl is optionally independently substituted with 1, 2 or 3 Rx;
- Rd is each independently selected from the group consisting of halogen, OH, CN, and NH2;
- Rx is each independently selected from the group consisting of halogen, OH, CN, and NH2;
- m is selected from the group consisting of 1, 2, and 3;
- and
- the carbon atom with “*” is a chiral carbon atom present in a form of a single (R) or (S) enantiomer or in a form enriched with one enantiomer.
10 more elements
Dependencies are inferred from the claim text.