Ferroptosis inhibitors—diarylamine para-acetamides

A compound of formula I, or a pharmaceutically acceptable salt, hydrate or stereoisomer thereof:

• wherein:
• R1 is NR′R″, wherein R′ and R″ are independently selected from substituted or unsubstituted C1-C9 alkyl, and substituted or unsubstituted C5-C12 aryl, or wherein R′ and R″ are linked to form a substituted or unsubstituted 4- to 9-membered heterocycle containing 1 to 4 heteroatoms selected from N, O, and S;
• R2-R9 are independently H, halogen, C1-C6 alkoxy, amino, C1-C6 alkylamino, di-(C1-C6 alkyl)amino, or substituted or unsubstituted C1-C6 alkyl;
• R10 is H, halogen, C1-C6 alkoxy, amino, C1-C6 alkylamino, di-(C1-C6 alkyl)amino, or unsubstituted C1-C6 alkyl;
• R11 is H, OH, or substituted or unsubstituted C1-C4 alkyl;
• R12 is C1-C6 alkoxy, amino, C1-C6 alkylamino, di-(C1-C6 alkyl)amino, C1-C6 alkanoyl, carbamoyl, carboxyl, amido, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C9 cycloalkyl, or substituted or unsubstituted 3- to 9-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, and S;
• R11 and R12 are optionally joined to form a substituted or unsubstituted 3- to 18-membered heterocycle containing 1 to 4 heteroatoms selected from N, O, and S;
• and
• X1-X5 and Y1-Y5 are C;
• wherein the substituents are in a number ranging from 0 to 3, each independently selected from halogen, —R′, —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, —SiR′R″R″′, —OC(O)R′, —C(O)R′, —CO2R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R″′, —NR′—SO2NR″′, —NR″CO2R′, —NH—C(NH2)═NH, —NR′C(NH2)=NH, —NH—C(NH2)=NR′, —S(O)R′, —SO2R′, —SO2NR′R″, —NR″SO2R, —CN, —NO2, —N3, —CH(Ph)2, perfluoro(C1-C4)alkoxy, and perfluoro(C1-C4)alkyl;
• wherein R′, R″ and R″′ each independently refer to hydrogen, unsubstituted (C1-C8)alkyl, (C1-C8)alkyl substituted with one to three halogens, unsubstituted C6-C14 aryl, C6-C14 aryl substituted with one to three halogens, unsubstituted C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkoxy groups, or C6-C14 aryl-(C1-C4)alkyl groups, wherein when R′ and R″ are attached to the same nitrogen atom, they are optionally combined with the nitrogen atom to form a 5-, 6- or 7-membered ring.