Aromatic sulphonamides derivatives that inhibits PDI A3, their synthesis and use

An N,N-disubstituted aromatic sulphonamide, wherein the N,N-disubstituted aromatic sulphonamide is selected from the group consisting of:

• Methyl 1-(4-butoxyphenyl)sulfonylaziridine-2-carboxylate;
• 1-(4-Nitrophenyl)sulfonylaziridine-2-carboxamide;
• Methyl 1-(4-butylphenyl)sulfonylaziridine-2-carboxylate;
• Methyl 1-[[6-(dimethylamino)-5-formyl-2-naphthyl]sulfonyl]aziridine-2-carboxylate;
• and
• Methyl 1-[[5-(dimethylamino)-2-naphthyl]sulfonyl]aziridine-2-carboxylate.