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US 12,715,847 B2Granted
Antibacterial compounds
AssigneeBlacksmith Medicines, Inc.
InventorsMin Teng, Baskar Nammalwar, Xiaoming Li, Christian Perez, David T. Puerta
Life of this patent
Estimating the term…
Abstract
Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.
Claims20
A compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein:
- R1 is C1-C4 alkyl;
- R2a and R2b are each independently hydrogen, halogen, or C1-C4 alkyl;
- R3 is hydrogen, —(C1-C4 alkylene)-OH, or —(C1-C4 alkylene)-NH2;
- R4 is hydrogen or C1-C4 alkyl;
- each R5 and R6 is independently hydrogen, halogen, or C1-C4 alkyl;
- R7 is C1-C6 alkyl, C1-C6 alkoxy, C1-C6 heteroalkyl, C3-C6 cycloalkyl, 4- to 6-membered heterocycloalkyl, —O—(C3-C6 cycloalkyl), —O-(4- to 6-membered heterocycloalkyl), —(C1-C4 alkylene)-(C3-C6 cycloalkyl), —(C1-C4 alkylene)-(4- to 6-membered heterocycloalkyl), —O—(C1-C4 alkylene)-(C3-C6 cycloalkyl), —O—(C1-C4 alkylene)-(4- to 6-membered heterocycloalkyl), —(C1-C4 alkylene)-O—(C3-C6 cycloalkyl), or —(C1-C4 alkylene)-O-(4- to 6-membered heterocycloalkyl);
- wherein the alkyl, alkoxy, heteroalkyl, cycloalkyl, or heterocycloalkyl is unsubstituted or substituted by 1, 2, or 3 groups independently selected from —OR8, —N(R8)2, —CO2R8, —CON(R8)2, —CH2N(R8)2, —NHCOR8, —NHSO2R8, —CH2CN, C1-C4 alkyl, C1-C4 hydroxyalkyl, —C(═O)—C1-C4 hydroxyalkyl, C1-C4 methoxyalkyl, and C1-C4 aminoalkyl;
- each R8 is independently hydrogen, C1-C4 alkyl, —C(═O)—C1-C4 alkyl, or 4- to 6-membered heterocycloalkyl, wherein the alkyl or heterocycloalkyl is unsubstituted or substituted by 1, 2, 3, or 4 groups independently selected from —F, —CN, —OH, —CH2OH, —NH2, —OMe, —N(CH3)2, —CO2H, —CONH2, —SO2CH3, —C(═NH) NH2, phenyl, and monocyclic heteroaryl which is unsubstituted or substituted by 1 or 2 groups selected from —F, —CN, —OH, —NH2, —OMe, —N(CH3)2, —CO2H, —CONH2, and —SO2CH3;
- or two R8 attached to the same nitrogen are taken together to form a 4- to 6-membered heterocycloalkyl which is unsubstituted or substituted by 1, 2, or 3 groups independently selected from —F, —CN, —OH, —NH2, —OMe, —CO2H, —CONH2, and —SO2CH3;
- s is 1 or 2;
- and
- t is 1 or 2.
10 more elements
Dependencies are inferred from the claim text.