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US 12,714,994 B2Granted
Devices and methods for reversible assembly of a flowcell
Assignee10x Genomics, Inc.
InventorsSiyuan Xing, Pratomo Putra Alimsijah, Denis Pristinski, David Morgan, Rajiv Bharadwaj, Augusto Manuel Tentori, Francis Marcogliese, Yiran Zhang
Life of this patent
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Abstract
Flowcell devices configured for reversible assembly, and methods of assembly, disassembly, and use thereof are provided. The methods and devices allow the interior of the flowcell device to be accessed without damaging, or otherwise disturbing sensitive samples and surfaces.
Claims16
A device comprising:
- a fluidic interface layer having a top surface, a bottom surface, and at least one side surface;
- a substrate layer having a top surface, a bottom surface, and at least one side surface;
- and
- a gasket disposed between the bottom surface of the fluidic interface layer and the top surface of the substrate layer, wherein a first portion of the gasket is wrapped over the at least one side surface of the fluidic interface layer and at least a portion of the top surface of the fluidic interface layer.
1 more element
A device comprising:
- a fluidic interface layer having a top surface, a bottom surface, and at least one side surface, wherein the fluidic interface layer comprises at least one inlet at a first end and at least one outlet at a second end, wherein the fluidic interface layer comprises a vacuum port;
- a substrate layer having a top surface, a bottom surface, and at least one side surface;
- and
- a gasket disposed between the bottom surface of the fluidic interface layer and the top surface of the substrate layer, wherein the gasket comprises one or more voids defining a flow path extending from the first end to the second end, wherein the gasket comprises a vacuum channel extending around each of the one or more voids and fluidically coupled to the vacuum port, wherein the contact between the gasket and the substrate layer is reversible, and wherein the device is configured to be sealed by applying negative pressure to the vacuum port thereby forming a fluid tight seal between the fluidic interface layer, the substrate layer, and the gasket.
1 more element
A device comprising:
- a substrate layer;
- a fluidic interface layer;
- a gasket disposed therebetween;
- and
- a release fluid channel, wherein the gasket comprises a first void defining a flow path.
2 more elements
Dependencies are inferred from the claim text.