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US 12,714,783 B2Granted
Drug delivery system
AssigneeInsulet Corporation
InventorsJohn Richard Bussiere, Eduardo Luis Latouche, Seyedmohammadali Aghvami, Renwei Liu
Life of this patent
Estimating the term…
Abstract
Methods and devices for dispensing a therapeutic composition from within a sealed container and drug delivery systems are described. The device and the method for dispensing a therapeutic composition from within a sealed container comprises a container configured to hold a therapeutic composition and include a first septum, a needle, a tube and an expandable membrane configured to expand out of the tube into an interior volume of the container to displace the therapeutic composition out of the container through the needle.
Claims20
A device comprising:
- a container configured to hold a therapeutic composition, the container comprising a first septum;
- a needle;
- a tube configured to be displaced to break a frangible barrier;
- and
- an expandable membrane disposed at least partially in the tube;
- and
- a reaction chamber including a first reactant and a second reactant separated by the frangible barrier, wherein the first reactant and the second reactant are configured to generate a gas when mixed after the frangible barrier is broken,
- wherein the container is configured to be displaced towards the needle and the tube to pierce the first septum of the container with the needle and the tube, and wherein when the tube pierces the first septum the expandable membrane is configured to expand out of the tube into an interior volume of the container to displace the therapeutic composition out of the container through the needle.
5 more elements
A method for expelling a therapeutic composition from a container, the method comprising:
- piercing a first septum of the container with a needle and a tube, wherein piercing the first septum with the tube causes the tube to be displaced and break a frangible barrier separating a first reactant and a second reactant in a reaction chamber;
- allowing the first and second reactants to mix and generate a gas in response to breaking the frangible barrier;
- expanding a flexible membrane from the tube into an interior volume of the container using the gas to pressurize an interior volume of the container;
- and
- flowing the therapeutic composition out of the interior volume of the container through the needle.
2 more elements
A filling device selectively couplable to a drug delivery device, the filling device comprising:
- a container configured to hold a therapeutic composition, the container comprising a first septum;
- a needle;
- a tube;
- and
- an expandable membrane disposed at least partially in the tube,
- wherein the container is configured to be displaced towards the needle and the tube to pierce the first septum of the container with the needle and the tube, and wherein when the tube pierces the first septum the expandable membrane is configured to expand out of the tube into an interior volume of the container to displace the therapeutic composition out of the container through the needle;
- and
- a removable housing coupled to the drug delivery device, and configured to be removed with the filling device from the drug delivery device after providing the therapeutic composition to a reservoir of the drug delivery device.
5 more elements
A device comprising:
- a housing;
- a container disposed in the housing and configured to hold a therapeutic composition, the container comprising a first septum disposed on a first surface of the container;
- and
- a drive system operatively connected to container, wherein the drive system includes:
- a drive housing including a first drive housing portion and a second drive housing portion;
- a lock including a first lock portion associated with the first drive housing portion and a second lock portion associated with the second drive housing portion, wherein the lock selectively retains the first drive housing portion and the second drive housing portion in a first retracted configuration when the lock is in a locked configuration;
- and
- a mechanical potential energy source disposed in the drive housing between the first drive housing portion and the second drive housing portion, wherein when the lock is moved to an unlocked configuration, the mechanical potential energy source displaces the second drive housing portion to displace the container, and the first drive housing portion is a thrust plate and the second drive housing portion is a loading cup.
5 more elements
A device comprising:
- a housing;
- a container disposed in the housing and configured to hold a therapeutic composition, the container comprising a first septum disposed on a first surface of the container;
- and
- a drive system operatively connected to container, wherein the drive system includes:
- a drive housing including a first drive housing portion and a second drive housing portion;
- a lock including a first lock portion associated with the first drive housing portion and a second lock portion associated with the second drive housing portion, wherein the lock selectively retains the first drive housing portion and the second drive housing portion in a first retracted configuration when the lock is in a locked configuration;
- and
- a mechanical potential energy source disposed in the drive housing between the first drive housing portion and the second drive housing portion, and when the lock is moved to an unlocked configuration, the mechanical potential energy source displaces the second drive housing portion to displace the container, wherein the first lock portion is a slot formed in the first drive housing portion and the second lock portion is a mechanically interfering structure that is rotatably connected to the second drive housing portion, and the second lock portion is rotatable between the locked configuration and the unlocked configuration.
5 more elements
Dependencies are inferred from the claim text.