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US 12,714,759 B2Granted
Combination therapy for treating cancer
AssigneeCity of Hope
InventorsJohn E. Shively, Maciej Kujawski, Megan Minnix, Paul Yazaki
Life of this patent
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Abstract
Provided herein, inter alia, are radionuclide-labeled antibodies, immunocytokines, and methods for treating cancer using combination therapy with the radionuclide-labeled antibodies and the immunocytokines.
Claims20
A humanized anti-carcinoembryonic antigen (CEA) antibody, wherein the humanized anti-CEA antibody is bonded to an alpha-emitting radionuclide;
- wherein the humanized anti-CEA antibody has a CDR-L1 as set forth in SEQ ID NO:1, a CDR-L2 as set forth in SEQ ID NO:2, a CDR-L3 as set forth in SEQ ID NO:3, a CDR-H1 as set forth in SEQ ID NO:4, a CDR-H2 as set forth in SEQ ID NO:5 or SEQ ID NO:7, and a CDR-H3 as set forth in SEQ ID NO:6.
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of:
- (i) a first anti-carcinoembryonic antigen (CEA) antibody bonded to an alpha-emitting radionuclide;
- wherein the alpha-emitting radionuclide is 225Ac, 212Pb, 210At, 211At, 226Th, 227Th, 212Bi, 213Bi, 223Ra, 224Ra, 149Tb, or 230U, and
- (ii) an immunocytokine comprising a second anti-carcinoembryonic antigen (CEA) antibody covalently bonded to a cytokine;
- wherein the cytokine is IL-2, IL-4, IL-7, IL-9, IL-12, IL-15, IL-21, IL-33, TNF-α, TGF-β, interferon-γ, or interferon-α;
- wherein the first anti-CEA antibody and the second anti-CEA antibody independently have:
- (a) a variable light chain domain of SEQ ID NO:8 and a variable heavy chain domain of SEQ ID NO:9;
- (b) a variable light chain domain of SEQ ID NO:8 and a variable heavy chain domain of SEQ ID NO:10;
- or
- (c) a variable light chain domain of SEQ ID NO:11 and a variable heavy chain domain of SEQ ID NO:12
- wherein the immunocytokine is administered to the subject after the first anti-CEA antibody bonded to the alpha-emitting radionuclide is administered to the subject.
7 more elements
Dependencies are inferred from the claim text.