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US 12,714,758 B2Granted
DOTA-hapten compositions for anti-DOTA/anti-tumor antigen bispecific antibody pretargeted radioimmunotherapy
AssigneeMemorial Sloan Kettering Cancer Center
InventorsSteven Larson, Darren Veach, Sarah Taldone, Ouathek Ouerfelli, Guangbin Yang, Nai-Kong Cheung, Brian Santich, Hong Xu
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Abstract
The present disclosure provides compositions and methods for the detection and treatment of cancer. Specifically, the compositions of the present technology include novel compounds that may be complexed with a radioisotope. Also disclosed herein are methods of the using the DOTA-haptens of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy.
Claims20
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein
- M1 is a chelated 175Lu3+, 45Sc3+, 69Ga3+, 71Ga3+, 89Y3+, 113In3+, 115In3+, 139La3+, 136Ce3+, 138Ce3+, 140Ce3+, 142Ce3+, 151Eu3+, 153Eu3+, 159Tb3+, 154Gd3+, 155Gd3+, 156Gd3+, 157Gd3+, 158Gd3+ or 60Gd3+;
- R1 is
- X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, X18, X19, X20, X21, X22, X23, X24, X25, X26, X27, X28, X29, X30, X31, X32, X33, X34, X35, and X36 are each independently a lone pair of electrons or H;
- Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, and Y9 are each independently S or O;
- Q1 is S or O;
- and
- n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, or 22.
5 more elements
Dependencies are inferred from the claim text.