Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR)
AssigneeBaylor Research Institute
InventorsSangKon Oh, Dapeng Li, Jacques Banchereau, Gerard Zurawski, Sandra Zurawski
Life of this patent
Estimating the term…
Abstract
The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
Claims5
An anti-DC-ASGPR immunoglobulin or DC-ASGPR-binding fragment thereof having a myelin basic protein autoantigen attached to the immunoglobulin or fragment, wherein the immunoglobulin or fragment comprises an immunoglobulin variable heavy chain region domain (VH) and a variable light chain region domain (VL), and wherein the VH and VL comprises the VH and VL from a heavy and light chain having the amino acid sequence of SEQ ID NO:5 and 6, respectively, SEQ ID NO:7 and 8, respectively, SEQ ID NO:9 and 10, respectively, or SEQ ID NO:
- 11 and SEQ ID NO:
- 12, respectively.
Dependencies are inferred from the claim text.